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Urolithin A 500mg Softgels

The only compound on earth proven to clear damaged mitochondria and replace them with new, fully functional ones. 

bolt More Energy & Endurance 

shield Less Inflammation, Better Recovery

location_on Sharper Mental Clarity

bedtime Better Sleep Quality

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A naturally occurring compound that activates mitophagy, the process of clearing damaged mitochondria and replacing them with new ones. Your gut bacteria can produce it from foods like pomegranates, but only 40% of people make it naturally. Direct supplementation bypasses the guesswork.

Clear. Rebuild. Perform. It removes damaged mitochondria, triggers your body to build new ones, and increases the energy available to every cell. The only compound proven to activate mitophagy in humans

Week 1: Absorbed and active at a cellular level. 

Week 3: Immune cell composition measurably improved. 

Month 2: Energy and recovery differences start showing. 

Month 4: Full clinical effects on strength, endurance, and inflammation.

Published in JAMA, Nature, Cell, and Springer. 25 human clinical trials. 2,200+ participants. 18 years of research. Every major claim backed by randomized, double-blind, placebo-controlled data.

Your body has 10 million billion mitochondria. They power every cell. Every year you age, they break down faster than your body replaces them. That's where your energy goes. That's why inflammation builds. That's why recovery slows down.

“Urolithin A is one of the only nutritional compounds where the science behind its cellular mechanism is increasingly supported by clinical research.”

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93%
More Energy of participants felt a noticeable boost in daily energy with more endurance.
98%
Stronger of participants felt stronger without making any changes to their training. 
91%
Recovered of participants reported better sleep, less inflammation, stronger immune system. 
95%
Sharper of participants noticed sharper focus and improved mental clarity. 
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The Only Compound Proven To Clear Damaged Mitochondria And Rebuild Them Stronger

18 years of clinical research in every capsule. 25 human trials. 2,200+ participants. 

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How One Compound Rebuilds Your Cellular Engine

Step 1: Clear

Urolithin A activates mitophagy, your body's natural process for identifying and removing damaged mitochondria that are producing less energy and more waste.

Step 2: Rebuild

With damaged mitochondria cleared, your cells trigger mitochondrial biogenesis, producing new, fully functional mitochondria to replace what was lost.

Step 3: Perform

More healthy mitochondria means more energy available to every system in your body. Muscles, brain, immune cells, recovery. Everything runs better.

Why Urolithin A?

ENHANSE™ ENHANSE™
Creatine Creatine
COQ10 COQ10
NAD+/NMN NAD+/NMN
Increases Muscle Strength
Improves Endurance
Partial
Reduces Chronic Inflammation
Partial
Rejuvenates Immune Function
Improves Cellular Energy Production
Partial
Partial
Partial
Replaces Damaged Mitochondria
Addresses Root Cause of Age-Related Decline
Partial
Partial
Makes Your Other Supplements Work Harder
 

What People Are Saying

See how people are making Enhanse Urolithin A part of their daily wellness routine.

  •  

    An easy addition to my morning routine

    I take it with breakfast every morning and that's really all there is to it. It's easy to remember, no fuss, and has become one of those small things I actually look forward to. Glad I started.

    Customer avatar
    Daniel W.
    Verified Customer
  •  

    An easy addition to my morning routine

    I take it with breakfast every morning and that's really all there is to it. It's easy to remember, no fuss, and has become one of those small things I actually look forward to. Glad I started.

    Customer avatar
    Daniel W.
    Verified Customer
  •  

    An easy addition to my morning routine

    I take it with breakfast every morning and that's really all there is to it. It's easy to remember, no fuss, and has become one of those small things I actually look forward to. Glad I started.

    Customer avatar
    Daniel W.
    Verified Customer

    What To Expect With Enhanse™

    Activation

    Urolithin A is absorbed within 6 hours of your first dose. Mitophagy pathways begin activating at a cellular level. Your body is starting the cleanup.

    Benefits:

    • UA and its metabolites detected in plasma, confirming absorption and bioavailability.
    • Mitophagy signals begin identifying damaged mitochondria for removal.
    • Acylcarnitine levels start shifting, an early marker of improved mitochondrial efficiency.
    • No noticeable changes yet. The process is cellular, not perceptual.

    First Response

    Your immune system is the first to respond. By day 28, measurable changes in immune cell composition are already visible in blood work.

    Benefits:

    • Naive CD8+ T cells increase, a sign of immune rejuvenation.
    • Fatty acid oxidation capacity up 14.7% in immune cells.
    • Natural killer cell count raised.
    • Some users begin noticing subtle improvements in energy and recovery.

    Turning Point

    This is where most users report first feeling the difference. Endurance improvements begin showing in the clinical data. Inflammation markers are trending down.

    Benefits:

    • Peak VO2 improvement already manifesting at the 500mg dose.
    • Muscle endurance measurably improving in hand and leg muscles.
    • CRP beginning to separate from placebo.
    • Energy feels more consistent. Recovery between sessions noticeably faster.

    Momentum

    The gap between you and baseline is widening. Strength, endurance, and inflammation are all moving in the right direction.

    Benefits:

    • Strength gains accelerating toward the 12% improvement seen at 4 months.
    • Inflammation continuing to drop while placebo group trends upward.
    • Mitochondrial gene expression significantly upregulated in skeletal muscle.
    • Recovery, energy, and physical performance feel reliably different from month one.

    Full Clinical Effect

    This is the dose and duration used in the landmark trials. You're now at the performance level the published data showed.

    Benefits:

    • 12% increase in muscle strength without exercise change.
    • 10% improvement in peak aerobic endurance.
    • CRP significantly reduced while placebo increased 22%.
    • Plasma acylcarnitines and ceramides reduced, indicating improved mitochondrial efficiency.

    Compounding

    Mitochondrial biogenesis is ongoing. Your body is continuously clearing damaged mitochondria and building new ones. The benefits maintain and build.

    Benefits:

    • New mitochondria replacing old ones on an ongoing cycle.
    • Strength, endurance, and inflammation benefits maintain with continued use.
    • Immune resilience stays elevated as long as supplementation continues.
    • Every system that runs on cellular energy continues to benefit.

    The Clinical Evidence

    Urolithin A        Placebo

    • Strength & Endurance You Can Feel

      12% stronger. 10% more aerobic endurance. In 4 months. No change to exercise routine. 88 participants in a randomized, double-blind, placebo-controlled trial.

      ✓ Clinical Result

    • Inflammation That Finally Goes Down

      CRP, a key marker of systemic inflammation, dropped in the Urolithin A group while rising 22% in placebo. Two lines going in opposite directions over 4 months. 66 participants.

      ✓ Clinical Result

    • Your Supplements Actually Working

      Every supplement you take depends on cellular energy to be absorbed and used. Urolithin A measurably increased maximal ATP production in 4 months across 66 participants in a double-blind trial.

      ✓ Clinical Result

    • An Immune System That Fights Back

      Naive CD8+ T cells increased. Fatty acid oxidation capacity up 14.7%. Natural killer cell count raised. All in 28 days. 50 participants in a randomised, placebo-controlled trial.

      ✓ Clinical Result

      What Experts Are Saying About Urolithin A

      The clinical data on this compound is unlike anything I've seen in the supplement space. We’re talking randomized controlled trials showing measurable strength gains in people who didn't change their exercise routine. That almost never happens.

      Integrative Longevity Physician, DO

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      Have Questions? We've Got Answers.

      Choosing the right supplement matters. Here you'll find answers about Urolithin A, how it works, what's inside, and how to get the most from your daily routine.

      Urolithin A is a naturally occurring compound produced by gut bacteria when you eat foods like pomegranates, berries, and walnuts. However, only about 40% of people produce it naturally. It is the only compound clinically proven to activate mitophagy, the process of clearing damaged mitochondria and triggering your body to build new ones.

      Urolithin A is absorbed within hours and begins activating mitophagy at a cellular level in the first week. Immune cell improvements were measured at 28 days. Most users report noticeable changes in energy and recovery around month 2. Full clinical effects on strength, endurance, and inflammation were seen at 4 months in the published trials.

      Yes. Urolithin A works at the mitochondrial level, which is upstream of most other supplements. It improves the cellular energy production that every other supplement depends on to be absorbed and utilized. It pairs well with creatine, CoQ10, omega-3s, and protein. No known interactions have been reported across multiple clinical trials.

      Only about 40% of people have the right gut bacteria to convert pomegranate polyphenols into Urolithin A. Even those who can produce it naturally generate far less than the clinical dose. Direct supplementation delivers 6x more Urolithin A than pomegranate juice and bypasses the guesswork entirely.

      Urolithin A has FDA GRAS (Generally Recognized as Safe) status. It has been tested across multiple randomized, double-blind, placebo-controlled clinical trials with no serious adverse events reported. Every batch of Enhanse is third-party tested for purity, potency, and heavy metals.

      Enhanse comes with a 90-day money-back guarantee. If you're not satisfied for any reason, contact us for a full refund. No questions asked.